Metabolic activation of islet cells improves resistance against oxygen radicals or streptozocin, but not nitric oxide.
نویسندگان
چکیده
منابع مشابه
Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro.
When cultures of pancreatic islet cells are exposed to the nitric oxide donor sodium nitroprusside, to enzymatically generated reactive oxygen intermediates or to streptozotocin cell lysis occurs after 4-12 h. We report here that a heat shock at 43 degrees C for 90 min reduces cell lysis from nitric oxide (0.45 mM sodium nitroprusside) by 70%, from reactive oxygen intermediates (12 mU xanthine ...
متن کاملRodent and human mast cells produce functionally significant intracellular reactive oxygen species but not nitric oxide.
In immunity, reactive oxygen species (ROS) and nitric oxide (NO) are important antimicrobial agents and regulators of cell signaling and activation pathways. However, the cellular sources of ROS and NO are much debated. Particularly, there is contention over whether mast cells, key secretory cells in allergy and immunity, can generate these chemical species, and if so, whether they are of funct...
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Interest in the role of free radicals in rheumatoid arthritis (RA) stems from the seminal work of McCord,' who noted the decreased viscosity of synovial fluid in RA patients and showed that a similar decrease could be produced by exposing synovial fluid, or solutions of hyaluronic acid, to a system generating superoxide radical, 02-. McCord's observations led to interest in the use of intraarti...
متن کاملEffect of hyperbaric oxygen treatment on nitric oxide and oxygen free radicals in rat brain.
Oxygen (O(2)) at high pressures acts as a neurotoxic agent leading to convulsions. The mechanism of this neurotoxicity is not known; however, oxygen free radicals and nitric oxide (NO) have been suggested as contributors. This study was designed to follow the formation of oxygen free radicals and NO in the rat brain under hyperbaric oxygen (HBO) conditions using in vivo microdialysis. Male Spra...
متن کاملSimilar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide.
Pulmonary manifestations of oxygen toxicity were studied and quantified in rats breathing >98% O(2) at 1, 1.5, 2, 2.5, and 3 ATA to test our hypothesis that different patterns of pulmonary injury would emerge, reflecting a role for central nervous system (CNS) excitation by hyperbaric oxygen. At 1.5 atmosphere absolute (ATA) and below, the well-recognized pattern of diffuse pulmonary damage dev...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 1996
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.81.11.8923845